Yes, when the serum is designed to respond specifically to LED light at the cellular level. LED exposure increases cellular energy (ATP) and skin permeability, creating a window where targeted actives can function more efficiently. Light-activated serums are formulated to take advantage of this state by supporting processes like collagen signaling, moisture retention, and barrier repair while treatment is happening. This combination allows LED sessions to work more effectively, leading to more noticeable improvements in skin firmness, clarity, and overall texture.